Cellular hypoxia reprograms drug response and reveals curcumin-driven cancer stem-cell-associated marker enrichment in oral squamous cell carcinoma

Figure 2 Treatment induced cytotoxicity in OECM-1 cells under normoxic and hypoxic conditions. A: Single treatments of increasing concentrations of carboplatin and curcumin under normoxia; B: Single treatments of increasing concentrations of carboplatin and curcumin under hypoxia; C: Combination treatment with increasing doses of curcumin and fixed 0.1 mmol/L carboplatin under normoxia; D: Combination treatment with increasing doses of curcumin and fixed 0.1 mmol/L carboplatin under hypoxia.