Cellular hypoxia reprograms drug response and reveals curcumin-driven cancer stem-cell-associated marker enrichment in oral squamous cell carcinoma

doi:10.4252/wjsc.121991

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World Journal of Stem Cells

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1948-0210

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World J Stem Cells. Aug 26, 2026; 18(8): 121991
Published online Aug 26, 2026. doi: 10.4252/wjsc.121991

Table 1 Cytotoxic potency and maximal efficacy of curcumin, carboplatin, and combined treatment in oral squamous carcinoma cells under normoxic and hypoxic conditions, mean ± SD

	IC₅₀ (μM)		Maximal cytotoxic efficacy (%)
	Normoxic	Hypoxic	Normoxic	Hypoxic
Curcumin	137 ± 22	110 ± 3.1	77.4 ± 3.1	76.1 ± 4.0
Carboplatin	81.9 ± 5.0	670 ± 489	73.9 ± 1.0	42.4 ± 6.6
Curcumin + carboplatin	129 ± 48	410 ± 205	77.89 ± 8.4	82.7 ± 4.9

Values were derived from nonlinear regression using a variable-slope four-parameter model with the bottom plateau constrained to ≥ 0% viability. OECM-1, oral squamous cell carcinoma cell line used in this study. IC₅₀: Half-maximal inhibitory concentration.

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Citation: Alharbi HS, Rahman I, AlSheddi MA, Henidi H, Alkahtani MM, Al Makhlafi Z, ElRefai S, Altwaim SA, Alnofaie HS, Salem HM, Omar MG, Alturki A, Talic H, Aladhyani G, Alotaibi F, Basuhail H, Alotaibi R, Alturki N, Alharbi A, Alsultan R, Albassam SK. Cellular hypoxia reprograms drug response and reveals curcumin-driven cancer stem-cell-associated marker enrichment in oral squamous cell carcinoma. World J Stem Cells 2026; 18(8): 121991
URL: https://www.wjgnet.com/1948-0210/full/v18/i8/121991.htm
DOI: https://dx.doi.org/10.4252/wjsc.121991

Alharbi HS, Rahman I, AlSheddi MA, Henidi H, Alkahtani MM, Al Makhlafi Z, ElRefai S, Altwaim SA, Alnofaie HS, Salem HM, Omar MG, Alturki A, Talic H, Aladhyani G, Alotaibi F, Basuhail H, Alotaibi R, Alturki N, Alharbi A, Alsultan R, Albassam SK. Cellular hypoxia reprograms drug response and reveals curcumin-driven cancer stem-cell-associated marker enrichment in oral squamous cell carcinoma. World J Stem Cells 2026; 18(8): 121991 [DOI: 10.4252/wjsc.121991]

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