From mesenchymal stem cells to myoblast cell sheets: A next-generation regenerative concept for fistulizing Crohn’s disease

doi:10.4252/wjsc.121648

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Aug 26, 2026; 18(8): 121648
Published online Aug 26, 2026. doi: 10.4252/wjsc.121648

Table 3 Comparison between mesenchymal stem cell therapy and myoblast cell sheet therapy

Item	MSC therapy	Myoblast cell sheet therapy
Main effect	Immunomodulation and improvement of the local inflammatory environment	Local repair with potential muscle layer reconstruction
Delivery	Usually local injection; cells may be easily lost	Transplanted as a cell sheet, with better local retention
Repair pattern	Regulatory repair	Potential structural support and repair
Evidence in CD	Supported by several clinical studies	Direct evidence remains limited
Potential role	Promotes fistula closure and inflammation control	May support tissue reconstruction in complex fistulas

MSC: Mesenchymal stem cell; CD: Crohn’s disease.

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Citation: Zhang BL, Kobayashi S, Li LY, Li TY, Ogawa S, Miyamoto D, Hasegawa K, Yamaguchi S, Adachi T, Eguchi S, Kanetaka K. From mesenchymal stem cells to myoblast cell sheets: A next-generation regenerative concept for fistulizing Crohn’s disease. World J Stem Cells 2026; 18(8): 121648
URL: https://www.wjgnet.com/1948-0210/full/v18/i8/121648.htm
DOI: https://dx.doi.org/10.4252/wjsc.121648

Zhang BL, Kobayashi S, Li LY, Li TY, Ogawa S, Miyamoto D, Hasegawa K, Yamaguchi S, Adachi T, Eguchi S, Kanetaka K. From mesenchymal stem cells to myoblast cell sheets: A next-generation regenerative concept for fistulizing Crohn’s disease. World J Stem Cells 2026; 18(8): 121648 [DOI: 10.4252/wjsc.121648]

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