From mesenchymal stem cells to myoblast cell sheets: A next-generation regenerative concept for fistulizing Crohn’s disease

doi:10.4252/wjsc.121648

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Aug 26, 2026; 18(8): 121648
Published online Aug 26, 2026. doi: 10.4252/wjsc.121648

Table 2 Comparative studies of mesenchymal stem cell sheets and cell suspensions across different disease models

Ref.	Model	MSC source	Comparison	Outcome type	Main outcome
Gao et al[62], 2022	Porcine myocardial infarction	hUC-MSC	Cell sheet vs suspension	Functional recovery	Cell sheets improved cardiac function and reduced infarct size more effectively than MSC suspension
Takemura et al[66], 2020	Rat diabetic nephropathy	AD-MSC	Cell sheet vs IV suspension	Anti-inflammatory/anti-fibrotic	Cell sheets showed greater attenuation of renal inflammation and fibrosis than suspended MSCs
Imafuku et al[65], 2019	Rat renal ischemia-reperfusion injury	BM-MSC	Cell sheet vs IV suspension	Anti-fibrotic	Cell sheets more effectively reduced renal fibrosis and preserved microvasculature than MSC suspension
Chen et al[63], 2017	Mouse skin wound/subcutaneous implantation	AD-MSC	Cell sheet vs suspension	Retention/paracrine activity	Cell sheets exhibited higher cell retention and stronger paracrine factor secretion than suspended MSCs
Long et al[64], 2014	Mouse critical-sized femoral defect	BM-MSC	Cell sheet vs suspension	Structural regeneration	Cell sheets promoted superior bone regeneration and graft integration compared with MSC suspension
Qi et al[67], 2014	Rabbit cartilage/meniscal defect	BM-MSC	Cell sheet vs suspension	Cartilage repair	Cell sheets achieved better matrix deposition and defect repair than injected MSCs

Overall, mesenchymal stem cell sheet-based delivery showed superior therapeutic efficacy compared with mesenchymal stem cell suspension, as evidenced by improved cell retention, enhanced paracrine activity, and better tissue repair. MSC: Mesenchymal stem cell; hUC-MSC: Human umbilical cord-derived mesenchymal stem cell; AD-MSC: Adipose-derived mesenchymal stem cell; BM-MSC: Bone marrow-derived mesenchymal stem cell.

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Citation: Zhang BL, Kobayashi S, Li LY, Li TY, Ogawa S, Miyamoto D, Hasegawa K, Yamaguchi S, Adachi T, Eguchi S, Kanetaka K. From mesenchymal stem cells to myoblast cell sheets: A next-generation regenerative concept for fistulizing Crohn’s disease. World J Stem Cells 2026; 18(8): 121648
URL: https://www.wjgnet.com/1948-0210/full/v18/i8/121648.htm
DOI: https://dx.doi.org/10.4252/wjsc.121648

Zhang BL, Kobayashi S, Li LY, Li TY, Ogawa S, Miyamoto D, Hasegawa K, Yamaguchi S, Adachi T, Eguchi S, Kanetaka K. From mesenchymal stem cells to myoblast cell sheets: A next-generation regenerative concept for fistulizing Crohn’s disease. World J Stem Cells 2026; 18(8): 121648 [DOI: 10.4252/wjsc.121648]

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