Stem/progenitor cell-driven immune microenvironment remodeling in sepsis-associated acute respiratory distress syndrome

doi:10.4252/wjsc.121124

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World Journal of Stem Cells

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1948-0210

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World J Stem Cells. Aug 26, 2026; 18(8): 121124
Published online Aug 26, 2026. doi: 10.4252/wjsc.121124

Table 3 Imbalance of immune microenvironment and changes of inflammatory factors, mean ± SD

Indicators	Moderate group (n = 111)	Severe group (n = 89)	t	P value
Th17/Treg ratio	1.38 (1.18-1.74)	2.05 (1.73-2.54)	-7.842	< 0.001
CD4+T cell ratio (%)	41.88 ± 6.68	35.49 ± 7.86	6.213	< 0.001
CD8+T cell ratio (%)	26.38 ± 5.68	29.02 ± 5.47	3.321	0.001
IL-6 (pg/mL)	101.70 (75.17-135.41)	183.11 (143.88-245.16)	-8.156	< 0.001
TNF-α (pg/mL)	28.93 (25.96-36.76)	40.82 (32.90-54.50)	-6.734	< 0.001
IL-10 (pg/mL)	13.86 (10.65-19.34)	15.64 (13.03-22.77)	-1.982	0.049

Th17: T helper 17 cell; Treg: Regulatory T cells; IL: Interleukin; TNF-α: Tumor necrosis factor-α.

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Citation: Li WX, Jiang SC, Fan SL, Xing YX, Gong L. Stem/progenitor cell-driven immune microenvironment remodeling in sepsis-associated acute respiratory distress syndrome. World J Stem Cells 2026; 18(8): 121124
URL: https://www.wjgnet.com/1948-0210/full/v18/i8/121124.htm
DOI: https://dx.doi.org/10.4252/wjsc.121124

Li WX, Jiang SC, Fan SL, Xing YX, Gong L. Stem/progenitor cell-driven immune microenvironment remodeling in sepsis-associated acute respiratory distress syndrome. World J Stem Cells 2026; 18(8): 121124 [DOI: 10.4252/wjsc.121124]

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