Stem/progenitor cell-driven immune microenvironment remodeling in sepsis-associated acute respiratory distress syndrome

doi:10.4252/wjsc.121124

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World Journal of Stem Cells

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1948-0210

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World J Stem Cells. Aug 26, 2026; 18(8): 121124
Published online Aug 26, 2026. doi: 10.4252/wjsc.121124

Table 1 General information and disease severity of two groups, n (%)/mean ± SD

Indicators	Moderate group (n = 111)	Severe group (n = 89)	Statistical values	P value
Gender			χ² = 0.002	0.964
Male	77 (69.37)	62 (69.66)
Female	34 (30.63)	27 (30.34)
History of COPD	16 (14.41)	17 (19.10)	χ² = 0.788	0.375
Diabetes	30 (27.03)	34 (38.20)	χ² = 2.835	0.092
Chronic kidney disease	9 (8.11)	24 (26.97)	χ² = 12.750	< 0.001
Immunosuppressive state	7 (6.31)	10 (11.24)	χ² = 1.543	0.214
Age (years)	64.34 ± 11.14	66.97 ± 8.74	t = 1.822	0.070
SOFA score	8.81 ± 2.12	10.59 ± 2.39	t = 5.575	< 0.001
APACHE II score	19.45 ± 4.60	23.70 ± 5.91	t = 5.719	< 0.001
PaO₂/FiO₂ (mmHg)	150.97 ± 24.20	91.12 ± 10.55	t = 21.727	< 0.001
Blood lactic acid (mmol/L) on the first day of ICU admission	2.65 ± 0.93	3.62 ± 1.13	t = 6.659	< 0.001
Mechanical ventilation time (days)	8.24 ± 4.44	12.43 ± 5.57	t = 5.920	< 0.001
ICU stay (days)	11.77 ± 5.87	15.46 ± 6.40	t = 4.244	< 0.001

COPD: Chronic obstructive pulmonary disease; SOFA: Sequential organ failure assessment; APACHE II: Acute physiology and chronic health evaluation II; ICU: Intensive care unit.

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Citation: Li WX, Jiang SC, Fan SL, Xing YX, Gong L. Stem/progenitor cell-driven immune microenvironment remodeling in sepsis-associated acute respiratory distress syndrome. World J Stem Cells 2026; 18(8): 121124
URL: https://www.wjgnet.com/1948-0210/full/v18/i8/121124.htm
DOI: https://dx.doi.org/10.4252/wjsc.121124

Li WX, Jiang SC, Fan SL, Xing YX, Gong L. Stem/progenitor cell-driven immune microenvironment remodeling in sepsis-associated acute respiratory distress syndrome. World J Stem Cells 2026; 18(8): 121124 [DOI: 10.4252/wjsc.121124]

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