Mesenchymal stem cells therapy ameliorates esophageal dysmotility in gastroesophageal reflux disease by modulating smooth muscle contractility, alleviating senescence by targeting the DNMT3a-HIF1α axis

Figure 7 Transcriptomic analysis reveals mesenchymal stem cell-mediated pathway modulation. This figure presents a series of bioinformatics analyses comparing gene expression. A: Bar chart illustrating the number of significantly differentially expressed genes; B: Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of genes differentially expressed between the gastroesophageal reflux disease and normal groups (DGNG); C: KEGG pathway enrichment analysis of genes differentially expressed between the gastroesophageal reflux disease and mesenchymal stem cell groups (DGMG); D: Venn diagram illustrating the overlap between differentially expressed genes in DGNG and DGMG; E: KEGG pathway enrichment analysis of common genes; F: Trend analysis of common genes; G: Gene Ontology (GO) enrichment analysis specifically focusing on muscle-related clusters within common genes; H: GO enrichment analysis of common genes. The bubble plot shows enriched pathways, with bubble size indicating the number of genes and color representing the adjusted P-value in KEGG and GO enrichment analysis. DEGs: Differentially expressed genes; KEGG: Kyoto Encyclopedia of Genes and Genomes; CGS: Common genes; GERD: Gastroesophageal reflux disease; MSC: Mesenchymal stem cell; GO: Gene Ontology.