Very small embryonic-like stem cells: A predictor synergizing with complement and inflammatory factors for immunoglobulin A nephropathy prognosis

doi:10.4252/wjsc.120694

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World Journal of Stem Cells

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1948-0210

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World J Stem Cells. Aug 26, 2026; 18(8): 120694
Published online Aug 26, 2026. doi: 10.4252/wjsc.120694

Table 4 The predictive value of individual and combined detection of complement factor I, tumor necrosis factor-α and very small embryonic-like stem cells for end-stage renal disease in patients with immunoglobulin A nephropathy

Index	AUC	95%CI	P value	Sensitivity (%)	Specificity (%)
CFI	0.660	0.598-0.718	< 0.001^a	80.65	54.46
TNF-α	0.818	0.765-0.863	< 0.001^a	61.29	91.52
VSELs	0.749	0.691-0.801	< 0.001^a	61.29	95.54
Combination	0.916	0.875-0.947	< 0.001^a	83.87	90.62

^aP < 0.05.

AUC: Area under the curve; CI: Confidence interval; CFI: Complement factor I; TNF-α: Tumor necrosis factor-α; VSELs: Very small embryonic-like stem cells.

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Citation: Lou CL, Ren KX, Xu XQ, Wang XJ, Fan XP, Feng B, Hu PX, Zhou YJ. Very small embryonic-like stem cells: A predictor synergizing with complement and inflammatory factors for immunoglobulin A nephropathy prognosis. World J Stem Cells 2026; 18(8): 120694
URL: https://www.wjgnet.com/1948-0210/full/v18/i8/120694.htm
DOI: https://dx.doi.org/10.4252/wjsc.120694

Lou CL, Ren KX, Xu XQ, Wang XJ, Fan XP, Feng B, Hu PX, Zhou YJ. Very small embryonic-like stem cells: A predictor synergizing with complement and inflammatory factors for immunoglobulin A nephropathy prognosis. World J Stem Cells 2026; 18(8): 120694 [DOI: 10.4252/wjsc.120694]

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