Protective effect of hUC-MSCs regulating peritoneal mesothelial cell EMT through cGAS-STING signaling pathway in high glucose-induced peritoneal fibrosis

Figure 6 Effects of human umbilical cord-derived mesenchymal stem cells on peritoneal fibrosis and inflammatory cytokines in peritoneal fibrosis mice. A-C: Tracking the distribution of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) injected in mice. In vivo imaging of whole-body fluorescence (A). Fluorescent imaging of isolated organs (B). Fluorescence imaging of peritoneal tissues following hUC-MSC injection (C); D: Representative hematoxylin and eosin staining images; E: Representative Masson staining images; F and G: Tumor necrosis factor-alpha (F) and interleukin-6 (G) levels in peritoneal tissues were detected via enzyme-linked immunosorbent assay. Data are presented as mean ± SD. ^aP < 0.05 vs control; ^bP < 0.05 vs peritoneal fibrosis. hUC-MSCs: Human umbilical cord-derived mesenchymal stem cells; PF: Peritoneal fibrosis; HE: Hematoxylin and eosin; TNF-α: Tumor necrosis factor-alpha; IL-6: Interleukin-6.