Protective effect of hUC-MSCs regulating peritoneal mesothelial cell EMT through cGAS-STING signaling pathway in high glucose-induced peritoneal fibrosis

Figure 4 Effects of human umbilical cord-derived mesenchymal stem cells on activation of the cyclic GMP-AMP synthase-stimulator of interferon genes signaling pathway in various HMrSV5 cells. A: Cyclic GMP-AMP synthase mRNA; B: Stimulator of interferon genes mRNA levels detected via quantitative real-time polymerase chain reaction; C: Representative western blot bands; D and E: Quantitative analysis of protein expression: Cyclic GMP-AMP synthase (D); stimulator of interferon genes (E). Data are presented as mean ± SD. ^aP < 0.05 vs control; ^bP < 0.05 vs high glucose. hUC-MSCs: Human umbilical cord-derived mesenchymal stem cells; cGAS: Cyclic GMP-AMP synthase; STING: Stimulator of interferon genes; HG: High glucose.