Protective effect of hUC-MSCs regulating peritoneal mesothelial cell EMT through cGAS-STING signaling pathway in high glucose-induced peritoneal fibrosis

Figure 3 Effects of human umbilical cord-derived mesenchymal stem cells on epithelial-mesenchymal transition-related gene and protein expression in high glucose-treated HMrSV5 cells. A: Epithelial cadherin mRNA; B: Vimentin mRNA; C: Alpha-smooth muscle actin mRNA; D: Transforming growth factor-beta1 mRNA levels detected via quantitative real-time polymerase chain reaction; E: Representative western blot bands; F-I: Quantitative analysis of protein expression: Epithelial cadherin (F); vimentin (G); alpha-smooth muscle actin (H); transforming growth factor-beta1 (I). Data are presented as mean ± SD. ^aP < 0.05 vs control; ^bP < 0.05 vs high glucose. hUC-MSCs: Human umbilical cord-derived mesenchymal stem cells; HG: High glucose; E-cadherin: Epithelial cadherin; α-SMA: Alpha-smooth muscle actin; TGF-β1: Transforming growth factor-beta1.