Protective effect of hUC-MSCs regulating peritoneal mesothelial cell EMT through cGAS-STING signaling pathway in high glucose-induced peritoneal fibrosis

doi:10.4252/wjsc.120270

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World Journal of Stem Cells

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1948-0210

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Aug 26, 2026; 18(8): 120270
Published online Aug 26, 2026. doi: 10.4252/wjsc.120270

Table 1 Primer sequence

Gene symbol	Forward primer	Reverse primer
cGAS	AAGGCCTGCGCATTCAAAACT	AAGGATAGCCGCCATGTTTCTTCTT
STING	CCGGGAGGCAGAAGATGC	CAGGCACTCAGCAGAACCAA
IRF3	CACTGAAGCGGCTGTTGGT	AGGAGATGGTCTGCTGGAAG
TBK1	AGACAAAGCAGAACGTAGATTAGC	GCGTCATAGCTTTTGTGGCA
E-cadherin	AATCTGAAAGCGGCTGATACTG	CCATTCGTTCAAGTAGTCATAGTCC
Vimentin	GGATTCACTCCCTCTGGTTG	TGATGCTGAGAAGTTTCGTTG
α-SMA	GCGATCTCACCGACTACCTG	GCCGACTCCATACCGATGAA
TGF-β1	CCGACTACTACGCCAAGGA	AACCACTGCCGCACAACTC
β-actin	TGGCACCCAGCACAATGAA	CTAAGTCATAGTCCGCCTAGAAGCA

cGAS: Cyclic GMP-AMP synthase; STING: Stimulator of interferon genes; IRF3: Interferon regulatory factor 3; TBK1: TANK-binding kinase-1; E-cadherin: Epithelial cadherin; α-SMA: Alpha-smooth muscle actin; TGF-β1: Transforming growth factor-beta1.

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Citation: Dong FX, Zheng LL, Nie K, Wan JX. Protective effect of hUC-MSCs regulating peritoneal mesothelial cell EMT through cGAS-STING signaling pathway in high glucose-induced peritoneal fibrosis. World J Stem Cells 2026; 18(8): 120270
URL: https://www.wjgnet.com/1948-0210/full/v18/i8/120270.htm
DOI: https://dx.doi.org/10.4252/wjsc.120270

Dong FX, Zheng LL, Nie K, Wan JX. Protective effect of hUC-MSCs regulating peritoneal mesothelial cell EMT through cGAS-STING signaling pathway in high glucose-induced peritoneal fibrosis. World J Stem Cells 2026; 18(8): 120270 [DOI: 10.4252/wjsc.120270]

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