Breaking the cycle of radiation-induced bone death: Human amniotic mesenchymal stem cell-derived small extracellular vesicles restore coupled osteo-angiogenic regeneration

doi:10.4252/wjsc.119963

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Aug 26, 2026; 18(8): 119963
Published online Aug 26, 2026. doi: 10.4252/wjsc.119963

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Figure 2 Human amniotic mesenchymal stem cell-derived small extracellular vesicles mediate mitochondrial transfer to damaged osteoblasts and endothelial cells via tunneling nanotubes, restoring oxidative phosphorylation and ATP production, while promoting glycolytic adaptation in endothelial cells to support vascular repair. ROS: Reactive oxygen species; hAMSC-sEVs: Human amniotic mesenchymal stem cell-derived small extracellular vesicles; CXCR4: CXC receptor-4; ICAM-1: Intercellular adhesion molecule-1; PGC-1α: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; OXPHOS: Oxidative phosphorylation; HIF-1α: Hypoxia-inducible factor-1α.

Citation: Yang Y, Zhang GD, Yi L, Yang X, Han ZG, Song CY, Lu JS, Wang KY. Breaking the cycle of radiation-induced bone death: Human amniotic mesenchymal stem cell-derived small extracellular vesicles restore coupled osteo-angiogenic regeneration. World J Stem Cells 2026; 18(8): 119963
URL: https://www.wjgnet.com/1948-0210/full/v18/i8/119963.htm
DOI: https://dx.doi.org/10.4252/wjsc.119963

Yang Y, Zhang GD, Yi L, Yang X, Han ZG, Song CY, Lu JS, Wang KY. Breaking the cycle of radiation-induced bone death: Human amniotic mesenchymal stem cell-derived small extracellular vesicles restore coupled osteo-angiogenic regeneration. World J Stem Cells 2026; 18(8): 119963 [DOI: 10.4252/wjsc.119963]

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