Dynamic regulation of neural stem cell state transitions by NOTCH1-REST transcriptional axis

doi:10.4252/wjsc.117617

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Aug 26, 2026; 18(8): 117617
Published online Aug 26, 2026. doi: 10.4252/wjsc.117617

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Figure 11 Graphical abstract. Schematic of the multi-omics mechanism by which the neurogenic locus notch homolog protein 1-RE1-silencing transcription factor transcriptional axis regulates the dormancy-to-activation transition in human neural stem cells through epigenetic and metabolic reprogramming. Notch1: Neurogenic locus notch homolog protein 1; NSC: Neural stem cell; ATAC-seq: Assay for transposase-accessible chromatin using sequencing.

Citation: Xie ZC, Zhao XY, Xiong RH, Zhang XL, Yang W. Dynamic regulation of neural stem cell state transitions by NOTCH1-REST transcriptional axis. World J Stem Cells 2026; 18(8): 117617
URL: https://www.wjgnet.com/1948-0210/full/v18/i8/117617.htm
DOI: https://dx.doi.org/10.4252/wjsc.117617

Xie ZC, Zhao XY, Xiong RH, Zhang XL, Yang W. Dynamic regulation of neural stem cell state transitions by NOTCH1-REST transcriptional axis. World J Stem Cells 2026; 18(8): 117617 [DOI: 10.4252/wjsc.117617]

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