Dynamic regulation of neural stem cell state transitions by NOTCH1-REST transcriptional axis

Figure 10  RE1-silencing transcription factor inhibition significantly enhances motor function recovery following spinal cord injury in mice. A: Basso Mouse Scale score time-course line graph showing significantly higher scores in the RE1-silencing transcription factor inhibition group compared to controls, with the dual-intervention group exhibiting intermediate levels; B: Schematic illustration of footprint-based gait analysis; C: Quantification of hindlimb stride length, revealing a marked increase in the RE1-silencing transcription factor inhibition group; D: Representative hematoxylin and eosin staining images and quantitative analysis of cavity area; E: Representative GFAP immunofluorescence images and quantification of astroglial scar density. ^aP < 0.05, ^cP < 0.001, ^dP < 0.0001. BMS: Basso Mouse Scale; REST: RE1-silencing transcription factor.