Mesenchymal stem cell-derived extracellular vesicles as next generation drug delivery platforms

doi:10.4252/wjsc.120363

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Jul 26, 2026; 18(7): 120363
Published online Jul 26, 2026. doi: 10.4252/wjsc.120363

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Figure 3 Translational flow and key challenges in clinical development of mesenchymal stem cell-derived extracellular vesicles therapeutics. Schematic representation of the essential phases in the clinical translation of mesenchymal stem cell-derived extracellular vesicles including mesenchymal stem cell expansion, scalable extracellular vesicle production, purification using techniques like tangential flow filtration and size-exclusion chromatography, and quality control assessment. Key translational challenges are also emphasized as essential factors affecting successful application in clinical setting. MSC: Mesenchymal stem cell; EV: Extracellular vesicle; TFF: Tangential flow filtration; SEC: Size-exclusion chromatography.

Citation: Khan SA, Jha SK, Tiwari P, Narang J, Gupta V, Singh SK, Anand K, Rajendran RL, Gangadaran P, Parvez S. Mesenchymal stem cell-derived extracellular vesicles as next generation drug delivery platforms. World J Stem Cells 2026; 18(7): 120363
URL: https://www.wjgnet.com/1948-0210/full/v18/i7/120363.htm
DOI: https://dx.doi.org/10.4252/wjsc.120363

Khan SA, Jha SK, Tiwari P, Narang J, Gupta V, Singh SK, Anand K, Rajendran RL, Gangadaran P, Parvez S. Mesenchymal stem cell-derived extracellular vesicles as next generation drug delivery platforms. World J Stem Cells 2026; 18(7): 120363 [DOI: 10.4252/wjsc.120363]

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