Cancer stem cell-associated markers and their prognostic value in non-small cell lung cancer

Table 4 Cox regression analysis for influence on disease-free survival

Variables	Univariate HR (95%CI)	P value	Multivariate HR (95%CI)	P value
TNM stage II (vs stage I)	1.320 (0.900-1.930)	0.150	1.180 (0.830-1.680)	0.350
TNM stage III (vs stage I)	2.100 (1.450-3.040)	< 0.001	1.740 (1.210-2.510)	0.003
Poorly differentiated	1.400 (1.010-1.950)	0.043	1.150 (0.810-1.630)	0.430
CD133 high expression	1.280 (0.950-1.730)	0.100	1.120 (0.840-1.500)	0.410
ALDH1A1 high expression	1.460 (1.060-2.010)	0.020	1.350 (1.000-1.820)	0.048
SOX2 high expression	1.200 (0.920-1.580)	0.190	1.050 (0.800-1.380)	0.780
High CSC group (2-3 points)	1.600 (1.150-2.230)	0.006	1.420 (1.040-1.930)	0.028

HR: Hazard ratio; CI: Confidence interval; TNM: Tumor-node-metastasis; ALDH1A1: Aldehyde dehydrogenase 1A1; SOX2: SRY-box transcription factor 2; CSC: Cancer stem cell.