Cancer stem cell-associated markers and their prognostic value in non-small cell lung cancer

Table 3 Cox regression analysis for influence on overall survival

Variables	Univariate HR (95%CI)	P value	Multivariate HR (95%CI)	P value
Age (10 years per increase)	1.200 (0.950-1.520)	0.120	1.160 (0.910-1.490)	0.220
Male	1.120 (0.740-1.700)	0.590	1.080 (0.700-1.670)	0.730
Smoking history	1.300 (0.910-1.860)	0.150	1.180 (0.830-1.690)	0.350
Poorly differentiated	1.550 (1.060-2.260)	0.024	1.220 (0.850-1.760)	0.280
TNM stage II (vs stage I)	1.400 (0.900-2.180)	0.130	1.220 (0.770-1.930)	0.390
TNM stage III (vs stage I)	2.400 (1.520-3.780)	< 0.001	1.980 (1.235-3.173)	0.004
Postoperative adjuvant therapy	0.850 (0.560-1.300)	0.460	0.820 (0.530-1.270)	0.370
CD133 high expression	1.520 (1.070-2.170)	0.018	1.450 (1.033-2.037)	0.032
ALDH1A1 high expression	1.440 (1.050-1.980)	0.026	1.380 (1.001-1.902)	0.049
SOX2 high expression	1.280 (0.930-1.760)	0.120	1.150 (0.850-1.560)	0.360
CSC score (1 point for each increase)	1.360 (1.120-1.650)	0.002	1.250 (1.050-1.490)	0.012
High CSC group (2-3 points)	1.780 (1.200-2.640)	0.004	1.550 (1.078-2.228)	0.018

HR: Hazard ratio; CI: Confidence interval; TNM: Tumor-node-metastasis; ALDH1A1: Aldehyde dehydrogenase 1A1; SOX2: SRY-box transcription factor 2; CSC: Cancer stem cell.