Cancer stem cell-associated markers and their prognostic value in non-small cell lung cancer

doi:10.4252/wjsc.119550

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World Journal of Stem Cells

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1948-0210

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World J Stem Cells. Jun 26, 2026; 18(6): 119550
Published online Jun 26, 2026. doi: 10.4252/wjsc.119550

Table 2 Correlation between expression of cancer stem cell markers and clinical pathological indices, n (%)

Indices	Differentiation	CD133		χ²	P value	ALDH1A1		χ²	P value	SOX2		χ²	P value
Indices	Differentiation	High expression	Low expression	χ²	P value	High expression	Low expression	χ²	P value	High expression	Low expression	χ²	P value
Differentiation	Poorly	40 (55.56)	32 (44.44)	6.097	0.014	46 (63.89)	26 (36.11)	5.355	0.021	30 (41.67)	42 (58.33)	0.130	0.718
Differentiation	Moderately-well	48 (37.50)	80 (62.50)			60 (46.88)	68 (53.12)			50 (39.06)	78 (60.94)
Lymph node metastasis	Positive	46 (54.76)	38 (45.24)	6.808	0.009	56 (66.67)	28 (33.33)	10.859	0.001	40 (47.62)	44 (52.38)	3.503	0.061
Lymph node metastasis	Negative	42 (36.21)	74 (63.79)			50 (43.10)	66 (56.90)			40 (34.48)	76 (65.52)
TNM stage	Stage I-II	56 (39.44)	86 (60.56)			70 (49.30)	72 (50.70)			54 (38.03)	88 (61.97)
TNM stage	Stage III	32 (55.17)	26 (44.83)	4.138	0.042	36 (62.07)	22 (37.93)	2.697	0.101	26 (44.83)	32 (55.17)	0.793	0.373
Histological type	Squamous cell carcinoma	34 (47.22)	38 (52.78)	0.474	0.491	32 (44.44)	40 (55.56)	3.306	0.069	40 (55.56)	32 (44.44)	11.343	0.001
Histological type	Adenocarcinoma	54 (42.19)	74 (57.81)			74 (57.81)	54 (42.19)			40 (31.25)	88 (68.75)

TNM: Tumor-node-metastasis; ALDH1A1: Aldehyde dehydrogenase 1A1; SOX2: SRY-box transcription factor 2.

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Citation: Luo LL, Jiang SC, Li S, Zhang GY, Tang JJ, Guo YD. Cancer stem cell-associated markers and their prognostic value in non-small cell lung cancer. World J Stem Cells 2026; 18(6): 119550
URL: https://www.wjgnet.com/1948-0210/full/v18/i6/119550.htm
DOI: https://dx.doi.org/10.4252/wjsc.119550

Luo LL, Jiang SC, Li S, Zhang GY, Tang JJ, Guo YD. Cancer stem cell-associated markers and their prognostic value in non-small cell lung cancer. World J Stem Cells 2026; 18(6): 119550 [DOI: 10.4252/wjsc.119550]

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