Combining mitochondrial antioxidant mitoquinone and mesenchymal stem cell therapy for amelioration of radiation-induced lung injury: Synergistic regenerative strategy

doi:10.4252/wjsc.117622

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World Journal of Stem Cells

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1948-0210

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Jun 26, 2026; 18(6): 117622
Published online Jun 26, 2026. doi: 10.4252/wjsc.117622

Table 4 Comparison of fibrosis and inflammation indicators on day 28

Indicators	Model group (n = 20)	MitoQ group (n = 20)	MSCs group (n = 20)	Combination group (n = 20)	F value	P value
Collagen deposition area (%)	28.4 ± 3.1	18.7 ± 2.4	17.9 ± 2.3	12.3 ± 2.1	29.417	< 0.001
α-SMA (gray value)	2.18 ± 0.21	1.38 ± 0.15	1.31 ± 0.14	1.12 ± 0.14	31.128	< 0.001
TGF-β1 (gray value)	2.35 ± 0.26	1.42 ± 0.16	1.39 ± 0.15	1.18 ± 0.15	30.504	< 0.001
Inflammation score (0-4 points)	2.8 ± 0.6	1.6 ± 0.4	1.5 ± 0.3	0.9 ± 0.3	27.916	< 0.001

MitoQ: Mitoquinone; MSC: Mesenchymal stem cell; α-SMA: Α-smooth muscle actin; TGF-β1: Transforming growth factor-β1.

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Citation: Hu YL, Lin ZX, Zhang XY, Li GL, Liu WJ, Shi ZQ, Li XH, Yang ZZ. Combining mitochondrial antioxidant mitoquinone and mesenchymal stem cell therapy for amelioration of radiation-induced lung injury: Synergistic regenerative strategy. World J Stem Cells 2026; 18(6): 117622
URL: https://www.wjgnet.com/1948-0210/full/v18/i6/117622.htm
DOI: https://dx.doi.org/10.4252/wjsc.117622

Hu YL, Lin ZX, Zhang XY, Li GL, Liu WJ, Shi ZQ, Li XH, Yang ZZ. Combining mitochondrial antioxidant mitoquinone and mesenchymal stem cell therapy for amelioration of radiation-induced lung injury: Synergistic regenerative strategy. World J Stem Cells 2026; 18(6): 117622 [DOI: 10.4252/wjsc.117622]

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