Combining mitochondrial antioxidant mitoquinone and mesenchymal stem cell therapy for amelioration of radiation-induced lung injury: Synergistic regenerative strategy

doi:10.4252/wjsc.117622

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Jun 26, 2026; 18(6): 117622
Published online Jun 26, 2026. doi: 10.4252/wjsc.117622

Table 3 Comparison of mitochondrial function indexes on day 28

Indicators	Model group (n = 20)	MitoQ group (n = 20)	MSCs group (n = 20)	Combination group (n = 20)	F value	P value
JC-1 red-green ratio	0.52 ± 0.05	0.69 ± 0.06	0.71 ± 0.05	0.78 ± 0.06	32.148	< 0.001
ATP (nmol/mg protein)	3.12 ± 0.27	3.88 ± 0.29	3.95 ± 0.30	4.12 ± 0.31	28.672	< 0.001
Swelling/ridge fracture ratio (%)	36.8 ± 3.5	21.4 ± 2.7	19.8 ± 2.5	15.3 ± 2.2	30.506	< 0.001

MitoQ: Mitoquinone; MSC: Mesenchymal stem cell.

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Citation: Hu YL, Lin ZX, Zhang XY, Li GL, Liu WJ, Shi ZQ, Li XH, Yang ZZ. Combining mitochondrial antioxidant mitoquinone and mesenchymal stem cell therapy for amelioration of radiation-induced lung injury: Synergistic regenerative strategy. World J Stem Cells 2026; 18(6): 117622
URL: https://www.wjgnet.com/1948-0210/full/v18/i6/117622.htm
DOI: https://dx.doi.org/10.4252/wjsc.117622

Hu YL, Lin ZX, Zhang XY, Li GL, Liu WJ, Shi ZQ, Li XH, Yang ZZ. Combining mitochondrial antioxidant mitoquinone and mesenchymal stem cell therapy for amelioration of radiation-induced lung injury: Synergistic regenerative strategy. World J Stem Cells 2026; 18(6): 117622 [DOI: 10.4252/wjsc.117622]

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