Combining mitochondrial antioxidant mitoquinone and mesenchymal stem cell therapy for amelioration of radiation-induced lung injury: Synergistic regenerative strategy

doi:10.4252/wjsc.117622

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World Journal of Stem Cells

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1948-0210

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Jun 26, 2026; 18(6): 117622
Published online Jun 26, 2026. doi: 10.4252/wjsc.117622

Table 2 Comparison of oxidative stress indicators on day 28

Indicators	Model group (n = 20)	MitoQ group (n = 20)	MSCs group (n = 20)	Combination group (n = 20)	F value	P value
ROS (fluorescence intensity)	1.78 ± 0.14	1.24 ± 0.10	1.22 ± 0.09	1.18 ± 0.09	28.416	< 0.001
MDA (nmol/mg protein)	5.62 ± 0.41	3.98 ± 0.36	3.99 ± 0.35	3.71 ± 0.31	25.317	< 0.001
GSH (μmol/g protein)	18.32 ± 1.24	22.71 ± 1.15	23.05 ± 1.16	23.71 ± 1.15	26.145	< 0.001

MitoQ: Mitoquinone; MSC: Mesenchymal stem cell; ROS: Reactive oxygen species; MDA: Malondialdehyde; GSH: Glutathione.

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Citation: Hu YL, Lin ZX, Zhang XY, Li GL, Liu WJ, Shi ZQ, Li XH, Yang ZZ. Combining mitochondrial antioxidant mitoquinone and mesenchymal stem cell therapy for amelioration of radiation-induced lung injury: Synergistic regenerative strategy. World J Stem Cells 2026; 18(6): 117622
URL: https://www.wjgnet.com/1948-0210/full/v18/i6/117622.htm
DOI: https://dx.doi.org/10.4252/wjsc.117622

Hu YL, Lin ZX, Zhang XY, Li GL, Liu WJ, Shi ZQ, Li XH, Yang ZZ. Combining mitochondrial antioxidant mitoquinone and mesenchymal stem cell therapy for amelioration of radiation-induced lung injury: Synergistic regenerative strategy. World J Stem Cells 2026; 18(6): 117622 [DOI: 10.4252/wjsc.117622]

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