Combining mitochondrial antioxidant mitoquinone and mesenchymal stem cell therapy for amelioration of radiation-induced lung injury: Synergistic regenerative strategy

Table 1 Comparison of lung function indexes in different groups at different time points

Indicators	Time point	Model group (n = 20)	MitoQ group (n = 20)	MSCs group (n = 20)	Combination group (n = 20)	Group effect F(P)	Time effect F(P)	Interaction F(P)
Raw (cmH2O∙second/mL)	7 days	2.12 ± 0.16	1.95 ± 0.14	1.92 ± 0.13	1.84 ± 0.15	42.317 (< 0.001)	31.582 (< 0.001)	12.441 (0.003)
	14 days	2.31 ± 0.17	1.92 ± 0.13	1.88 ± 0.14	1.77 ± 0.13
	28 days	2.45 ± 0.18	1.89 ± 0.13	1.94 ± 0.14	1.72 ± 0.12
Crs (mL/cmH2O)	7 days	0.025 ± 0.003	0.028 ± 0.003	0.029 ± 0.004	0.030 ± 0.003	38.502 (< 0.001)	28.476 (< 0.001)	10.825 (0.004)
	14 days	0.023 ± 0.003	0.029 ± 0.003	0.029 ± 0.004	0.031 ± 0.003
	28 days	0.021 ± 0.003	0.028 ± 0.003	0.029 ± 0.004	0.031 ± 0.004

MitoQ: Mitoquinone; MSC: Mesenchymal stem cell.