Therapeutic effects of human amniotic epithelial cell-derived and umbilical cord blood mesenchymal stem cell-derived exosomes on preeclamptic rats

doi:10.4252/wjsc.116526

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World Journal of Stem Cells

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1948-0210

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Jun 26, 2026; 18(6): 116526
Published online Jun 26, 2026. doi: 10.4252/wjsc.116526

Table 5 Content of cytokines in placental tissues, mean ± SD

Cytokine	NP	PE	hAECs-exos	hucbMSCs-exos
PLGF (pg/mL)	50.46 ± 4.45	36.47 ± 4.84^a	42.28 ± 5.89^a^,^b	42.17 ± 3.38^a^,^b
VEGF (pg/mL)	57.89 ± 9.37	32.06 ± 5.40^a	44.60 ± 9.94^a^,^b	41.06 ± 9.39^a^,^b
SOD (ng/mL)	1.90 ± 0.20	1.34 ± 0.12^a	1.69 ± 0.25^a^,^b	1.58 ± 0.11^a^,^b
MDA (nmol/mL)	0.61 ± 0.07	0.99 ± 0.16^a	0.86 ± 0.11^a^,^b	0.86 ± 0.10^a^,^b

^aP < 0.05, compared to the normal pregnancy group.

^bP < 0.05, compared to the preeclampsia group.

PLGF: Placental growth factor; VEGF: Vascular endothelial growth factor; SOD: Superoxide dismutase; MDA: Malondialdehyde; NP: Normal pregnancy; PE: Preeclampsia; hAECs-exos: Human amniotic epithelial cell exosomes; hucbMSCs-exos: Exosomes from mesenchymal stem cells derived from human umbilical cord blood.

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Citation: Han LY, Zhang WZ, Zhang Y, Zhong W, Sun JL, Shen J. Therapeutic effects of human amniotic epithelial cell-derived and umbilical cord blood mesenchymal stem cell-derived exosomes on preeclamptic rats. World J Stem Cells 2026; 18(6): 116526
URL: https://www.wjgnet.com/1948-0210/full/v18/i6/116526.htm
DOI: https://dx.doi.org/10.4252/wjsc.116526

Han LY, Zhang WZ, Zhang Y, Zhong W, Sun JL, Shen J. Therapeutic effects of human amniotic epithelial cell-derived and umbilical cord blood mesenchymal stem cell-derived exosomes on preeclamptic rats. World J Stem Cells 2026; 18(6): 116526 [DOI: 10.4252/wjsc.116526]

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