Therapeutic effects of human amniotic epithelial cell-derived and umbilical cord blood mesenchymal stem cell-derived exosomes on preeclamptic rats

doi:10.4252/wjsc.116526

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Jun 26, 2026; 18(6): 116526
Published online Jun 26, 2026. doi: 10.4252/wjsc.116526

Table 4 Levels of cytokines in serum, mean ± SD

Cytokine	NP	PE	hAECs-exos	hucbMSCs-exos
IL-6 (pg/mL)	93.18 ± 9.75	149.26 ± 13.71^a	120.15 ± 16.20^a^,^b	124.64 ± 9.73^a^,^b
IL-10 (pg/mL)	2.30 ± 0.58	0.87 ± 0.18^a	1.58 ± 0.39^a^,^b	1.41 ± 0.53^a^,^b
TNF-α (pg/mL)	7.30 ± 1.01	11.20 ± 1.48^a	8.96 ± 1.23^a^,^b	9.43 ± 1.95^a^,^b
sFlt-1 (ng/mL)	0.22 ± 0.05	0.43 ± 0.10^a	0.33 ± 0.09^a^,^b	0.32 ± 0.12^a^,^b

^aP < 0.05, compared to the normal pregnancy group.

^bP < 0.05, compared to the preeclampsia group.

IL: Interleukin; TNF: Tumor necrosis factor; sFlt-1: Soluble fms-like tyrosine kinase-1; NP: Normal pregnancy; PE: Preeclampsia; hAECs-exos: Human amniotic epithelial cell exosomes; hucbMSCs-exos: Exosomes from mesenchymal stem cells derived from human umbilical cord blood.

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Citation: Han LY, Zhang WZ, Zhang Y, Zhong W, Sun JL, Shen J. Therapeutic effects of human amniotic epithelial cell-derived and umbilical cord blood mesenchymal stem cell-derived exosomes on preeclamptic rats. World J Stem Cells 2026; 18(6): 116526
URL: https://www.wjgnet.com/1948-0210/full/v18/i6/116526.htm
DOI: https://dx.doi.org/10.4252/wjsc.116526

Han LY, Zhang WZ, Zhang Y, Zhong W, Sun JL, Shen J. Therapeutic effects of human amniotic epithelial cell-derived and umbilical cord blood mesenchymal stem cell-derived exosomes on preeclamptic rats. World J Stem Cells 2026; 18(6): 116526 [DOI: 10.4252/wjsc.116526]

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