Therapeutic effects of human amniotic epithelial cell-derived and umbilical cord blood mesenchymal stem cell-derived exosomes on preeclamptic rats

doi:10.4252/wjsc.116526

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Jun 26, 2026; 18(6): 116526
Published online Jun 26, 2026. doi: 10.4252/wjsc.116526

Table 2 Protein determination of 24-hour urine in each group of rats, mean ± SD

Group	GD4	GD8	GD11	GD15	GD18
NP	2.67 ± 0.49	2.91 ± 0.33	2.68 ± 0.55	2.76 ± 0.58	2.84 ± 0.59
PE	2.76 ± 0.29	4.46 ± 0.39^a	5.92 ± 0.68^a	7.07 ± 0.66^a	8.19 ± 1.07^a
hAECs-exos	2.77 ± 0.23	4.45 ± 0.73^a	6.18 ± 0.77^a	5.34 ± 0.76^a^,^b	4.70 ± 0.52^a^,^b
hucbMSCs-exos	2.67 ± 0.55	4.37 ± 0.46^a	6.24 ± 0.91^a	5.43 ± 0.71^a^,^b	4.94 ± 0.46^a^,^b

^aP < 0.05, compared to the normal pregnancy group.

^bP < 0.05, compared to the preeclampsia group.

GD: Gestational day; NP: Normal pregnancy; PE: Preeclampsia; hAECs-exos: Human amniotic epithelial cell exosomes; hucbMSCs-exos: Exosomes from mesenchymal stem cells derived from human umbilical cord blood.

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Citation: Han LY, Zhang WZ, Zhang Y, Zhong W, Sun JL, Shen J. Therapeutic effects of human amniotic epithelial cell-derived and umbilical cord blood mesenchymal stem cell-derived exosomes on preeclamptic rats. World J Stem Cells 2026; 18(6): 116526
URL: https://www.wjgnet.com/1948-0210/full/v18/i6/116526.htm
DOI: https://dx.doi.org/10.4252/wjsc.116526

Han LY, Zhang WZ, Zhang Y, Zhong W, Sun JL, Shen J. Therapeutic effects of human amniotic epithelial cell-derived and umbilical cord blood mesenchymal stem cell-derived exosomes on preeclamptic rats. World J Stem Cells 2026; 18(6): 116526 [DOI: 10.4252/wjsc.116526]

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