Therapeutic effects of human amniotic epithelial cell-derived and umbilical cord blood mesenchymal stem cell-derived exosomes on preeclamptic rats

doi:10.4252/wjsc.116526

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Jun 26, 2026; 18(6): 116526
Published online Jun 26, 2026. doi: 10.4252/wjsc.116526

Table 1 Measurement of systolic blood pressure in groups of rats at different gestational days, mean ± SD

Group	GD4	GD8	GD11	GD15	GD18
NP	111.75 ± 1.83	112.50 ± 3.42	114.50 ± 3.30	112.25 ± 4.95	113.00 ± 4.44
PE	112.63 ± 1.30	137.25 ± 2.44^a	143.00 ± 2.27^a	151.38 ± 3.74^a	155.38 ± 6.95^a
hAECs-exos	113.00 ± 3.96	139.25 ± 3.15^a	149.13 ± 3.91^a	130.88 ± 3.40^a^,^b	121.50 ± 4.14^a^,^b
hucbMSCs-exos	110.88 ± 2.42	138.25 ± 4.23^a	146.5 ± 4.66^a	128.38 ± 3.89^a^,^b	120.25 ± 4.98^a^,^b

^aP < 0.05, compared to the normal pregnancy group.

^bP < 0.05, compared to the preeclampsia group.

Results shown as mmHg. GD: Gestational day; NP: Normal pregnancy; PE: Preeclampsia; hAECs-exos: Human amniotic epithelial cell exosomes; hucbMSCs-exos: Exosomes from mesenchymal stem cells derived from human umbilical cord blood.

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Citation: Han LY, Zhang WZ, Zhang Y, Zhong W, Sun JL, Shen J. Therapeutic effects of human amniotic epithelial cell-derived and umbilical cord blood mesenchymal stem cell-derived exosomes on preeclamptic rats. World J Stem Cells 2026; 18(6): 116526
URL: https://www.wjgnet.com/1948-0210/full/v18/i6/116526.htm
DOI: https://dx.doi.org/10.4252/wjsc.116526

Han LY, Zhang WZ, Zhang Y, Zhong W, Sun JL, Shen J. Therapeutic effects of human amniotic epithelial cell-derived and umbilical cord blood mesenchymal stem cell-derived exosomes on preeclamptic rats. World J Stem Cells 2026; 18(6): 116526 [DOI: 10.4252/wjsc.116526]

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