Dysregulated circARF3/miR-27b-3p/YAP1 contributes to impaired osteogenic differentiation of periodontal ligament stem cells in periodontitis

Figure 1 Circular RNA ADP-ribosylation factor 3 expression is correlated with periodontitis. A and B: Expression levels of periodontal ligament stem cell surface markers including CD90, CD105, CD45, and CD34 in periodontal ligament stem cell from periodontitis patients (A) and healthy donors (B) identified by flow cytometry; C: Circular RNA ADP-ribosylation factor 3 expression in periodontitis tissues and heathy samples. ^bP < 0.01, compared with healthy group; D: Level of circular RNA ADP-ribosylation factor 3 at 0 hour, 24 hours, 7 days, 14 days, and 21 days after osteogenic induction. ^aP < 0.05, compared with 0 hour; ^bP < 0.01, compared with 0 hour. pPDSLC: Periodontitis periodontal ligament stem cell; hPDSLC: Healthy periodontal ligament stem cell; ARF3: ADP-ribosylation factor 3.