Expression of liver cancer stem cell markers and association with recurrence and survival in hepatocellular carcinoma

doi:10.4252/wjsc.v18.i5.119123

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World Journal of Stem Cells

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1948-0210

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. May 26, 2026; 18(5): 119123
Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.119123

Table 3 Multivariate Cox regression analysis (recurrence-free survival)

Variable	β	SE	Wald χ²	HR (95%CI)	P value
EpCAM positive	0.542	0.264	4.226	1.72 (1.03-2.88)	0.040
CD133 positive	0.140	0.278	0.254	1.15 (0.67-1.98)	0.614
CK19 positive	0.769	0.285	7.261	2.16 (1.23-3.78)	0.007
CD44 positive	0.115	0.270	0.183	1.12 (0.66-1.91)	0.669
Microvascular invasion	0.700	0.256	7.491	2.01 (1.22-3.32)	0.006
Tumor maximum diameter > 5 cm	0.447	0.262	2.916	1.56 (0.94-2.61)	0.088
Multifocal	0.116	0.281	0.170	1.12 (0.65-1.95)	0.680
AFP ≥ 400 ng/mL	0.208	0.450	0.214	1.23 (0.51-2.97)	0.644
Edmondson III-IV	-0.385	0.276	1.947	0.68 (0.40-1.17)	0.163

HR: Hazard ratio; CI: Confidence interval; AFP: Alpha-fetoprotein.

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Citation: Jia XQ, Han S, Shang YS, Kong FG, Qi L, Wang CL, Xiong WJ. Expression of liver cancer stem cell markers and association with recurrence and survival in hepatocellular carcinoma. World J Stem Cells 2026; 18(5): 119123
URL: https://www.wjgnet.com/1948-0210/full/v18/i5/119123.htm
DOI: https://dx.doi.org/10.4252/wjsc.v18.i5.119123

Jia XQ, Han S, Shang YS, Kong FG, Qi L, Wang CL, Xiong WJ. Expression of liver cancer stem cell markers and association with recurrence and survival in hepatocellular carcinoma. World J Stem Cells 2026; 18(5): 119123 [DOI: 10.4252/wjsc.v18.i5.119123]

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