Expression of liver cancer stem cell markers and association with recurrence and survival in hepatocellular carcinoma

doi:10.4252/wjsc.v18.i5.119123

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World Journal of Stem Cells

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1948-0210

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. May 26, 2026; 18(5): 119123
Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.119123

Table 2 Positive rate of cancer stem cell markers and correlation with invasive characteristics

Marker	Expression status	n (%)	MVI positive, n (%)	Edmondson III-IV, n (%)	AFP ≥ 400, n (%)
EpCAM	Positive	45 (34.09)	17 (37.78)	22 (48.89)	5 (11.11)
	Negative	87 (65.91)	35 (40.23)	36 (41.38)	9 (10.34)
	χ²		0.444	1.902	0.068
	P value		0.505	0.168	0.794
CD133	Positive	42 (31.82)	17 (40.48)	25 (59.52)	6 (14.29)
	Negative	90 (68.18)	35 (38.89)	33 (36.67)	8 (8.89)
	χ²		0.000	3.609	0.734
	P value		0.986	0.057	0.392
CK19	Positive	31 (23.48)	19 (61.29)	17 (54.84)	6 (19.35)
	Negative	101 (76.52)	33 (32.67)	41 (40.59)	8 (7.92)
	χ²		6.982	1.418	2.741
	P value		0.008	0.234	0.098
CD44	Positive	62 (46.97)	30 (48.39)	33 (53.23)	8 (12.90)
	Negative	70 (53.03)	22 (31.43)	25 (35.71)	6 (8.57)
	χ²		3.282	2.238	0.475
	P value		0.070	0.135	0.491

Edmondson III-IV demonstrated a moderate to low differentiation tendency. MVI: Microvascular invasion; AFP: Alpha-fetoprotein.

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Citation: Jia XQ, Han S, Shang YS, Kong FG, Qi L, Wang CL, Xiong WJ. Expression of liver cancer stem cell markers and association with recurrence and survival in hepatocellular carcinoma. World J Stem Cells 2026; 18(5): 119123
URL: https://www.wjgnet.com/1948-0210/full/v18/i5/119123.htm
DOI: https://dx.doi.org/10.4252/wjsc.v18.i5.119123

Jia XQ, Han S, Shang YS, Kong FG, Qi L, Wang CL, Xiong WJ. Expression of liver cancer stem cell markers and association with recurrence and survival in hepatocellular carcinoma. World J Stem Cells 2026; 18(5): 119123 [DOI: 10.4252/wjsc.v18.i5.119123]

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