Expression of liver cancer stem cell markers and association with recurrence and survival in hepatocellular carcinoma

doi:10.4252/wjsc.v18.i5.119123

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World Journal of Stem Cells

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1948-0210

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World J Stem Cells. May 26, 2026; 18(5): 119123
Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.119123

Table 1 Baseline characteristics of patients stratified by different levels of cancer stem cell expression, n (%)

Indices	CSC low expression (n = 76)	CSC high expression (n = 56)	Statistic	P value
Age (years)	55.05 ± 9.46	53.96 ± 9.76	t = 0.638	0.525
Gender
Male	59 (77.63)	40 (71.43)	χ² = 0.672	0.412
Female	17 (22.37)	16 (28.57)	χ² = 0.672	0.412
HBV infection
Yes	49 (64.47)	43 (76.79)	χ² = 2.369	0.124
No	27 (35.53)	13 (23.21)	χ² = 2.369	0.124
Liver cirrhosis
Yes	43 (56.58)	32 (57.14)	χ² = 0.004	0.948
No	33 (43.42)	24 (42.86)	χ² = 0.004	0.948
AFP (ng/mL)	97.71 (55.82-204.30)	106.71 (51.90-185.17)	Z = 2.230	0.640
AFP
< 400 ng/mL	66 (86.84)	54 (96.43)	χ² = 3.216	0.073
≥ 400 ng/mL	10 (13.16)	2 (3.57)	χ² = 3.216	0.073
Tumor maximum diameter (cm)	4.98 ± 2.43	5.62 ± 2.31	t = -1.537	0.127
Tumor maximum diameter
≤ 5 cm	42 (55.26)	21 (37.50)	χ² = 4.338	0.037
> 5 cm	34 (44.74)	35 (62.50)	χ² = 4.338	0.037
Multifocal
Yes	16 (21.05)	17 (30.36)	χ² = 1.452	0.228
No	60 (78.95)	39 (69.64)	χ² = 1.452	0.228
Microvascular invasion
Yes	26 (34.21)	26 (46.43)	χ² = 2.066	0.151
No	50 (65.79)	30 (53.57)	χ² = 2.066	0.151
Edmondson classification
Class I-II	49 (64.47)	25 (44.64)	χ² = 5.199	0.023
Class III-IV	27 (35.53)	31 (55.36)	χ² = 5.199	0.023

CSC: Cancer stem cell; HBV: Hepatitis B virus; AFP: Alpha-fetoprotein.

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Citation: Jia XQ, Han S, Shang YS, Kong FG, Qi L, Wang CL, Xiong WJ. Expression of liver cancer stem cell markers and association with recurrence and survival in hepatocellular carcinoma. World J Stem Cells 2026; 18(5): 119123
URL: https://www.wjgnet.com/1948-0210/full/v18/i5/119123.htm
DOI: https://dx.doi.org/10.4252/wjsc.v18.i5.119123

Jia XQ, Han S, Shang YS, Kong FG, Qi L, Wang CL, Xiong WJ. Expression of liver cancer stem cell markers and association with recurrence and survival in hepatocellular carcinoma. World J Stem Cells 2026; 18(5): 119123 [DOI: 10.4252/wjsc.v18.i5.119123]

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