Calcium dysregulation underlies phenotypic diversity in LQT2: Insights from induced pluripotent stem cell-derived cardiomyocytes of a KCNH2 p.Y427H family trio

doi:10.4252/wjsc.v18.i5.117584

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World Journal of Stem Cells

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1948-0210

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. May 26, 2026; 18(5): 117584
Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.117584

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Figure 6 Graphical abstract. PBMCs: Peripheral blood mononuclear cells; iPSCs: Induced pluripotent stem cells; iPSC-CMs: Induced pluripotent stem cell-derived cardiomyocytes; MEA: Multi-electrode array; APD: Action potential duration; cFPD: Corrected field potential duration; CaTD: Calcium transient duration; EADs: Early afterdepolarizations; VT: Ventricular tachycardia; TAs: Triggered arrhythmias; SICD: Subcutaneous implantable cardioverter defibrillator.

Citation: Li Q, Guo CT, Ren JC, Wang YF, Zhao ZJ, Lv CH, Wang QY, Liu Q, Li K, Yang J, He R, Liu FL, Lv TT, Zhang P. Calcium dysregulation underlies phenotypic diversity in LQT2: Insights from induced pluripotent stem cell-derived cardiomyocytes of a KCNH2 p.Y427H family trio. World J Stem Cells 2026; 18(5): 117584
URL: https://www.wjgnet.com/1948-0210/full/v18/i5/117584.htm
DOI: https://dx.doi.org/10.4252/wjsc.v18.i5.117584

Li Q, Guo CT, Ren JC, Wang YF, Zhao ZJ, Lv CH, Wang QY, Liu Q, Li K, Yang J, He R, Liu FL, Lv TT, Zhang P. Calcium dysregulation underlies phenotypic diversity in LQT2: Insights from induced pluripotent stem cell-derived cardiomyocytes of a KCNH2 p.Y427H family trio. World J Stem Cells 2026; 18(5): 117584 [DOI: 10.4252/wjsc.v18.i5.117584]

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