Hypoxic preconditioning restores the regenerative potential of aged adipose tissue derived mesenchymal stem cells

doi:10.4252/wjsc.v18.i5.117241

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. May 26, 2026; 18(5): 117241
Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.117241

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Figure 6 Wound-healing potential of adipose tissue derived mesenchymal stem cells. A: In young adipose tissue derived mesenchymal stem cells (ADMSCs) near-complete wound closure was observed within 24 hours (20 ×); B: Aged normoxia ADMSCs showed minimal wound closure even after 48 hours (20 ×); C: Aged hypoxia ADMSCs exhibited increased wound closure, although closure remained less than that of young ADMSCs (20 ×); D: Young ADMSC group showed significantly greater wound closure as compared to aged normoxia. Aged hypoxia ADMSCs group showed marked improvement in closure as compared to its counterpart aged normoxia ADMSC (P = 0.0007). Data are presented as mean ± SD. ^cP < 0.001. NS: Not significant.

Citation: Bashir B, Choudhery MS, Hussain I. Hypoxic preconditioning restores the regenerative potential of aged adipose tissue derived mesenchymal stem cells. World J Stem Cells 2026; 18(5): 117241
URL: https://www.wjgnet.com/1948-0210/full/v18/i5/117241.htm
DOI: https://dx.doi.org/10.4252/wjsc.v18.i5.117241

Bashir B, Choudhery MS, Hussain I. Hypoxic preconditioning restores the regenerative potential of aged adipose tissue derived mesenchymal stem cells. World J Stem Cells 2026; 18(5): 117241 [DOI: 10.4252/wjsc.v18.i5.117241]

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