Hypoxia-preconditioned adipose-derived stem cell exosomes promote osteogenic differentiation and bone formation in bone marrow mesenchymal stem cells through the Piezo1/Ca2+ signaling axis

doi:10.4252/wjsc.v18.i5.117045

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. May 26, 2026; 18(5): 117045
Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.117045

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Figure 4 Hypoxia-preconditioned exosomes mediate calcium influx by upregulating Piezo1. A: Immunofluorescence staining showing Piezo1 expression in bone marrow mesenchymal stem cells (scale bar: 100 μm); B: Western blot analysis and quantification of Piezo1 expression in bone marrow mesenchymal stem cells (n = 3, one-way ANOVA); C: Representative real-time fluorescence images of intracellular calcium dynamics in the same field of view (scale bar: 100 μm). ^cP < 0.001. Exos: Exosomes; HY-Exos: Hypoxia-preconditioned exosomes.

Citation: Taxi W, Sun J, Zhu YH, Zhang TC, Guo Y, Pan YL, Liu MM, Chen X, Zhang CL, Tong K, Wang LN, Jiang T, Ma Y. Hypoxia-preconditioned adipose-derived stem cell exosomes promote osteogenic differentiation and bone formation in bone marrow mesenchymal stem cells through the Piezo1/Ca²⁺ signaling axis. World J Stem Cells 2026; 18(5): 117045
URL: https://www.wjgnet.com/1948-0210/full/v18/i5/117045.htm
DOI: https://dx.doi.org/10.4252/wjsc.v18.i5.117045

Taxi W, Sun J, Zhu YH, Zhang TC, Guo Y, Pan YL, Liu MM, Chen X, Zhang CL, Tong K, Wang LN, Jiang T, Ma Y. Hypoxia-preconditioned adipose-derived stem cell exosomes promote osteogenic differentiation and bone formation in bone marrow mesenchymal stem cells through the Piezo1/Ca²⁺ signaling axis. World J Stem Cells 2026; 18(5): 117045 [DOI: 10.4252/wjsc.v18.i5.117045]

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