Hypoxia-preconditioned mesenchymal stem cell-derived exosomes attenuate myocardial ischemia/reperfusion injury by miR-29b-3p via PINK1/Parkin-mediated mitophagy

doi:10.4252/wjsc.v18.i5.116611

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. May 26, 2026; 18(5): 116611
Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.116611

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Figure 1 Characterization of exosome and hypoxia-preconditioned mesenchymal stem cell-derived exosomes. A: Schematic diagram of the isolation process for exosomes derived from mesenchymal stem cells; B: Size distribution chart of exosome (Exo) and hypoxia-preconditioned mesenchymal stem cell-derived Exo; C: Transmission electron micrographs of Exo and hypoxia-preconditioned mesenchymal stem cell-derived Exo. Scale bar: 200 nm; D: Western blot analysis of Alix, Tsg101, and CD9 expression in Exo and HPC-Exo. BM-MSC: Bone marrow mesenchymal stem cell; Exo: Normoxic exosomes; HPC-Exo: Hypoxia-preconditioned mesenchymal stem cells-derived exosomes; MSCs: Mesenchymal stem cells.

Citation: Wen W, Liu CX, Wang Y, Lu XJ, Yang C, Chen SJ, Jin ZT, Qu MY, Deng JY, Zhang Z. Hypoxia-preconditioned mesenchymal stem cell-derived exosomes attenuate myocardial ischemia/reperfusion injury by miR-29b-3p via PINK1/Parkin-mediated mitophagy. World J Stem Cells 2026; 18(5): 116611
URL: https://www.wjgnet.com/1948-0210/full/v18/i5/116611.htm
DOI: https://dx.doi.org/10.4252/wjsc.v18.i5.116611

Wen W, Liu CX, Wang Y, Lu XJ, Yang C, Chen SJ, Jin ZT, Qu MY, Deng JY, Zhang Z. Hypoxia-preconditioned mesenchymal stem cell-derived exosomes attenuate myocardial ischemia/reperfusion injury by miR-29b-3p via PINK1/Parkin-mediated mitophagy. World J Stem Cells 2026; 18(5): 116611 [DOI: 10.4252/wjsc.v18.i5.116611]

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