Erythropoietin-overexpressing mesenchymal stem cells accelerate diabetic wound healing via steroid signaling pathway modulation

Figure 5 Single-cell RNA sequencing analysis of skin wound tissue from diabetic mice. A: Uniform manifold approximation and projection clustering plot showing major cell populations identified by single-cell RNA sequencing in skin wound tissue from the diabetes mellitus, negative control mesenchymal stem cell, and erythropoietin-overexpressing mesenchymal stem cell groups; B: Proportional distribution of major cell populations in skin tissue; C: Proportional distribution of mononuclear phagocytes among the three groups; D: Heatmap illustrating differentially expressed genes in macrophage populations; E: Proportional distribution of macrophage subpopulations; F: Volcano plot showing differentially expressed genes in cluster 5 macrophages. NC-MSC: Negative control mesenchymal stem cell; EPO-MSC: Erythropoietin-overexpressing mesenchymal stem cell.