FOXP1 promotes the proliferation and self-renewal of spermatogonial stem cells via the nuclear factor kappa B pathway

doi:10.4252/wjsc.v18.i5.115482

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. May 26, 2026; 18(5): 115482
Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.115482

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Figure 3 Forkhead box P1 knockdown inhibited the self-renewal of spermatogonial stem cells in mice. A and B: Immunohistochemical staining showing the protein level changes of ETS variant gene 5 and promyelocytic leukemia zinc finger in mice testes after transfection with sh-FOXP1 lentivirus; C and D: Immunofluorescence staining of ETS variant gene 5 and promyelocytic leukemia zinc finger in mice testes after transfection with sh-FOXP1 lentivirus. Scale bars = 100 μm. FOXP1: Forkhead box P1; NC: Negative control; ETV5: ETS variant gene 5; PLZF: Promyelocytic leukemia zinc finger; DAPI: 4’6-diaminophenylindole.

Citation: Wu JH, Lin F, Wang YH, Xie JP, Guo SL, Liu PY. FOXP1 promotes the proliferation and self-renewal of spermatogonial stem cells via the nuclear factor kappa B pathway. World J Stem Cells 2026; 18(5): 115482
URL: https://www.wjgnet.com/1948-0210/full/v18/i5/115482.htm
DOI: https://dx.doi.org/10.4252/wjsc.v18.i5.115482

Wu JH, Lin F, Wang YH, Xie JP, Guo SL, Liu PY. FOXP1 promotes the proliferation and self-renewal of spermatogonial stem cells via the nuclear factor kappa B pathway. World J Stem Cells 2026; 18(5): 115482 [DOI: 10.4252/wjsc.v18.i5.115482]

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