Isolation and proteomic profiling of mesenchymal stem cell-derived extracellular vesicles: Unlocking new frontiers in regenerative and translational medicine

doi:10.4252/wjsc.v18.i5.114668

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World Journal of Stem Cells

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1948-0210

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. May 26, 2026; 18(5): 114668
Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.114668

Table 2 Common proteins related to regenerative medicine

Category	UniProt ID(s)	Gene symbol	Protein name	Regenerative function
ECM remodeling and structural support	P02452	COL1A1	Collagen type I alpha-1	Structural ECM, Wound healing, tissue strength
	P35568	FLNA	Filamin-A	Cytoskeletal remodeling, motility, tissue repair
	Q16363	ITGA6	Integrin alpha-6	Stem cell adhesion, marker of regenerative potential
	Q93052	ITGB1BP1	Integrin beta-1-binding protein 1	Integrin signaling in wound healing
Growth factor and regenerative signaling	P16234	PDGFRB	PDGF receptor beta	Angiogenesis, proliferation, repair
	P29320	SHC1	SHC-transforming protein 1	Growth factor adapter, survival, regeneration
	P37275	PPARG	Peroxisome proliferator-activated receptor gamma	Differentiation, tissue remodeling
	P42224	STAT1	STAT1	JAK/STAT repair and immune regulation
	P42229	STAT2	STAT2	Anti-viral and repair signaling
	Q13009	SMAD3	SMAD3	TGF-β pathway, fibrosis, repair
	Q13127	SMAD4	SMAD4	Central TGF-β/BMP signaling in regeneration
Chaperones and stress response	Q13464	HSP90AA1	Heat shock protein HSP90α	Protects stem cells, enhances survival in stress
Cell proliferation and stemness regulators	Q14999	NPM1	Nucleophosmin	Proliferation, ribosome biogenesis, stem cell support
Migration and tissue remodeling	P46934	IQGAP1	IQGAP1	Cell migration, cytoskeletal organization, repair
Migration and tissue remodeling	Q92841	LRP1	LDL receptor related protein 1	Neuro regeneration, ECM clearance, repair

ECM: Extracellular matrix; PDGF: Platelet-derived growth factor; JAK: Janus kinase; STAT: Signal transducer and activator of transcription; TGF: Transforming growth factor; BMP: Bone morphogenetic protein; HSP: Heat shock protein; LDL: Low-density lipoprotein.

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Citation: Sadat-Ali M, Al-Turki HA, Khan AA, Bannu SM, Vutharadhi S, Baig MM. Isolation and proteomic profiling of mesenchymal stem cell-derived extracellular vesicles: Unlocking new frontiers in regenerative and translational medicine. World J Stem Cells 2026; 18(5): 114668
URL: https://www.wjgnet.com/1948-0210/full/v18/i5/114668.htm
DOI: https://dx.doi.org/10.4252/wjsc.v18.i5.114668

Sadat-Ali M, Al-Turki HA, Khan AA, Bannu SM, Vutharadhi S, Baig MM. Isolation and proteomic profiling of mesenchymal stem cell-derived extracellular vesicles: Unlocking new frontiers in regenerative and translational medicine. World J Stem Cells 2026; 18(5): 114668 [DOI: 10.4252/wjsc.v18.i5.114668]

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