Hypoxia-conditioned extracellular vesicles from human amniotic membrane stem cells attenuate D-galactose-induced aging in mice

doi:10.4252/wjsc.v18.i4.117707

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World Journal of Stem Cells

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1948-0210

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Apr 26, 2026; 18(4): 117707
Published online Apr 26, 2026. doi: 10.4252/wjsc.v18.i4.117707

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Figure 6 Effects of extracellular vesicles on the brain acetylcholine, brain brain-derived neurotrophic factor, muscular brain-derived neurotrophic factor, and brain sirtuin 1 in D-galactose-induced aging rats on day 44. A: Effects of extracellular vesicles (EVs) on the brain acetylcholine in D-galactose (D-Gal)-induced aging rats on day 44; B: Effects of EVs on the brain brain-derived neurotrophic factor in D-Gal-induced aging rats on day 44; C: Effects of EVs on the muscular brain-derived neurotrophic factor in D-Gal-induced aging rats on day 44; D: Effects of EVs on the brain sirtuin 1 in D-Gal-induced aging rats on day 44. D-Gal (300 mg/kg) was subcutaneously administered every day for 6 weeks, and EVs (6 × 10⁸ particles/body) were intravenously injected at 2-week intervals (on days 0, 13, 26, and 41). ^aP < 0.05, compared with normal control; ^bP < 0.05, compared with D-galactose alone. ACh: Acetylcholine; BDNF: Brain-derived neurotrophic factor; SIRT1: Sirtuin 1; EVs: Extracellular vesicles; D-Gal: D-galactose.

Citation: Tsolmon KE, Bavuu Z, Kim SS, Jeong HS, Park D, Kim YB. Hypoxia-conditioned extracellular vesicles from human amniotic membrane stem cells attenuate D-galactose-induced aging in mice. World J Stem Cells 2026; 18(4): 117707
URL: https://www.wjgnet.com/1948-0210/full/v18/i4/117707.htm
DOI: https://dx.doi.org/10.4252/wjsc.v18.i4.117707

Tsolmon KE, Bavuu Z, Kim SS, Jeong HS, Park D, Kim YB. Hypoxia-conditioned extracellular vesicles from human amniotic membrane stem cells attenuate D-galactose-induced aging in mice. World J Stem Cells 2026; 18(4): 117707 [DOI: 10.4252/wjsc.v18.i4.117707]

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