Modulation of osteoarthritis-related microRNAs using locked nucleic acid-antisense oligonucleotides boosts chondrogenic lineage commitment of mesenchymal progenitors

Figure 2 Macroscopic appearance and size of micromasses at day 21 of chondrogenic differentiation. A: Representative stereomicroscope images (80 ×) of micromasses formed from control and locked nucleic acid-antisense oligonucleotides-transfected rat bone-marrow mesenchymal stem cells after 21 days in chondrogenic medium. Scale bar: 500 μm; B: Average micromass diameter for each condition. Diameters were measured in ImageJ along the longest axis on calibrated images. No obvious differences in diameter were detected across groups.