Mesenchymal stem cells alleviate renal injury of lupus nephritis mice by reconstructing the immune microenvironment of renal tissue

doi:10.4252/wjsc.v18.i4.115446

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Apr 26, 2026; 18(4): 115446
Published online Apr 26, 2026. doi: 10.4252/wjsc.v18.i4.115446

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Figure 4 Changes in immune cells in the spleens and kidney tissues of MRL/Ipr mice. A-D: Multiple immunofluorescence and quantitative analysis of regulatory T (Treg) (CD4+CD25+Foxp3+) (A and C); multiple immunofluorescence and quantitative analysis of T helper 17 (IL-17A+CD4+) (B and D); E: Flow cytometric analysis of the percentages of Treg (CD4+CD25+Foxp3+) in the spleen; F: Quantitative analysis of the percentages of Treg in the spleen. All data were expressed as mean ± SEM, ^aP < 0.05 vs lupus nephritis group, ^bP < 0.01 vs lupus nephritis group. LN: Lupus nephritis; UCMSCs: Umbilical cord mesenchymal stem cells; IL: Interleukin.

Citation: He LJ, Meng MY, Huang CK, Liu SY, Wang P, Long W, Gao H, Yang LS, He S, He Y, Guo YF, Zhao YY, Liu Y, Hu LR, Li L, Hou ZL, Wang WJ, Wang XD. Mesenchymal stem cells alleviate renal injury of lupus nephritis mice by reconstructing the immune microenvironment of renal tissue. World J Stem Cells 2026; 18(4): 115446
URL: https://www.wjgnet.com/1948-0210/full/v18/i4/115446.htm
DOI: https://dx.doi.org/10.4252/wjsc.v18.i4.115446

He LJ, Meng MY, Huang CK, Liu SY, Wang P, Long W, Gao H, Yang LS, He S, He Y, Guo YF, Zhao YY, Liu Y, Hu LR, Li L, Hou ZL, Wang WJ, Wang XD. Mesenchymal stem cells alleviate renal injury of lupus nephritis mice by reconstructing the immune microenvironment of renal tissue. World J Stem Cells 2026; 18(4): 115446 [DOI: 10.4252/wjsc.v18.i4.115446]

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