Exosomes of adipose-derived mesenchymal stem cells loaded with globular adiponectin improve islet function for type 2 diabetes

Figure 4 Restore pancreatic function and inhibit apoptosis. A: Representative images of hematoxylin and eosin staining of experimental groups showing morphological alterations of pancreatic islets; B: Immunohistochemistry staining showing positive insulin expression; C: Bar graphs representing insulin expression; D: Representative images of each group showing immunohistochemistry glucagon expression; E: Bar graphs representing glucagon expression; F: Bar graphs representing serum insulin levels after modeling and after therapeutic intervention; G: Bar graphs of HOMA-IR index expression by group; H: The EDU method was used to detect the apoptosis rate of pancreatic cells, scale bars = 50 μm; I: Bar graphs representing apoptosis rate. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001, vs the type 2 diabetes mellitus group respectively ; ^eP < 0.001, ^fP < 0.0001, vs the control group respectively (n = 3). T2DM: Type 2 diabetes mellitus; Exo: Exosome; gAd: Globular adiponectin; H&E: Hematoxylin and eosin.