Acupuncture improves transplanted neural stem cells in dementia mice by modulating hippocampal microenvironment via microRNA-124 mediated Notch and Wnt pathways

doi:10.4252/wjsc.v18.i3.114929

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Mar 26, 2026; 18(3): 114929
Published online Mar 26, 2026. doi: 10.4252/wjsc.v18.i3.114929

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Figure 2 Experiment operational flowchart: Timing of cell culture and transplantation as well as acupuncture intervention. SAMR1: Senescence-accelerated mice resistant 1; SAMP8: Senescence-accelerated mouse prone 8; RC: Senescence-accelerated mice resistant 1 control group; PC: Senescence-accelerated mouse prone 8 control group; PT: Senescence-accelerated mouse prone 8-neural stem cells transplantation group; PS: Senescence-accelerated mouse prone 8-sham transplantation group; PTA: Senescence-accelerated mouse prone 8-neural stem cells transplantation with acupoint group; PTN: Senescence-accelerated mouse prone 8-neural stem cells transplantation with non-acupoint group; PTAH: Senescence-accelerated mouse prone 8-neural stem cells transplantation with acupoint and microRNA-124 high expression group; PTAL: Senescence-accelerated mouse prone 8-neural stem cells transplantation with acupoint and microRNA-124 low expression group; PTAC: Senescence-accelerated mouse prone 8-neural stem cells transplantation with acupoint and microRNA-124 control group.

Citation: Li YJ, Chen X, Luo YY, Chang J, Liu SZ, Shan XQ, Song JJ, Hao N, Yan XH, Gao WL, Liu JW, Zhao L. Acupuncture improves transplanted neural stem cells in dementia mice by modulating hippocampal microenvironment via microRNA-124 mediated Notch and Wnt pathways. World J Stem Cells 2026; 18(3): 114929
URL: https://www.wjgnet.com/1948-0210/full/v18/i3/114929.htm
DOI: https://dx.doi.org/10.4252/wjsc.v18.i3.114929

Li YJ, Chen X, Luo YY, Chang J, Liu SZ, Shan XQ, Song JJ, Hao N, Yan XH, Gao WL, Liu JW, Zhao L. Acupuncture improves transplanted neural stem cells in dementia mice by modulating hippocampal microenvironment via microRNA-124 mediated Notch and Wnt pathways. World J Stem Cells 2026; 18(3): 114929 [DOI: 10.4252/wjsc.v18.i3.114929]

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