Acupuncture improves transplanted neural stem cells in dementia mice by modulating hippocampal microenvironment via microRNA-124 mediated Notch and Wnt pathways

Figure 1 Schematic diagram of the mechanism by which acupuncture regulates the downstream targets of microRNA-124. A: Notch signaling pathway; B: Wnt signaling pathway (canonical); C: Wnt signaling pathway (noncanonical); D: Notch and Wnt interaction; E: Cell cycle. AD: Alzheimer’s disease; NSCs: Neural stem cells; ADAM10: A disintegrin and metalloproteinase 10; Notch1: Notch homolog 1; HERP: Hairy/enhancer of split related protein; Hes1: Hairy and enhancer of split 1; Hes5: Hairy and enhancer of split 5; LRP5/6: Lipoprotein receptor-related protein 5/6; GSK3β: Glycogen synthase kinase 3β; TCF: T-cell factor; C-myc: Myc proto-oncogene; Cyclin D1: Cell cycle protein D1; Cylin D2: Cell cycle protein D2; PLC: Phospholipase C; PKC: Protein kinase C.