Therapeutic applications of mesenchymal stem cell-derived extracellular vesicles in pain management: A narrative review of emerging evidence and future directions

doi:10.4252/wjsc.v18.i2.116184

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Feb 26, 2026; 18(2): 116184
Published online Feb 26, 2026. doi: 10.4252/wjsc.v18.i2.116184

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Figure 6 Summary of how mesenchymal stem cell-derived extracellular vesicles (from source to response) help in pain management. Mesenchymal stem cells from various tissue sources secrete various types of extracellular vesicles, which contain bioactive cargo such as microRNAs, proteins, and lipids. These mesenchymal stem cell-derived extracellular vesicles target major pain-associated cells that result in therapeutic outcomes encompassing anti-inflammatory effects, neuroprotection, immunomodulation, and neuroprotection, thereby demonstrating their multifaceted mechanisms in reducing pain. MSCs: Mesenchymal stem cells; EVs: Extracellular vesicles; miRNAs: MicroRNAs; MSC-EVs: Mesenchymal stem cell-derived extracellular vesicles.

Citation: Khan SA, Gangadaran P, Tiwari P, Rajendran RL, Jamal A, Hattiwale SH, Anand K, Jha SK, Hong CM, Ahn BC, Parvez S. Therapeutic applications of mesenchymal stem cell-derived extracellular vesicles in pain management: A narrative review of emerging evidence and future directions. World J Stem Cells 2026; 18(2): 116184
URL: https://www.wjgnet.com/1948-0210/full/v18/i2/116184.htm
DOI: https://dx.doi.org/10.4252/wjsc.v18.i2.116184

Khan SA, Gangadaran P, Tiwari P, Rajendran RL, Jamal A, Hattiwale SH, Anand K, Jha SK, Hong CM, Ahn BC, Parvez S. Therapeutic applications of mesenchymal stem cell-derived extracellular vesicles in pain management: A narrative review of emerging evidence and future directions. World J Stem Cells 2026; 18(2): 116184 [PMID: 41808887 DOI: 10.4252/wjsc.v18.i2.116184]

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