Epiregulin enhances periodontal tissue regeneration by promoting bone marrow mesenchymal stem cell functions under inflammatory niches

doi:10.4252/wjsc.v18.i2.114032

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Feb 26, 2026; 18(2): 114032
Published online Feb 26, 2026. doi: 10.4252/wjsc.v18.i2.114032

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Figure 1 Supplementation with epiregulin enhanced the migration, chemotaxis, and osteogenic differentiation of mouse bone marrow stem cells under inflammatory conditions. A and B: Scratch-simulated wound migration assay results (n = 3, one-way analysis of variance [ANOVA]). Scale bar: 500 μm; C and D: Transwell chemotaxis assay results (n = 3, one-way ANOVA). Scale bar: 50 μm; E: Alizarin Red staining; F: Expression of osterix (OSX) and osteocalcin (OCN) was revealed in mouse bone marrow stem cells that were cultured in the inflammatory condition by western blotting. Error bars represent standard deviation. ^aP ≤ 0.05; ^bP ≤ 0.01. EREG: Epiregulin; TNF: Tumor necrosis factor.

Citation: Zhao YC, Li GY, Chen S, Wang YL, Feng JY, Cao Y. Epiregulin enhances periodontal tissue regeneration by promoting bone marrow mesenchymal stem cell functions under inflammatory niches. World J Stem Cells 2026; 18(2): 114032
URL: https://www.wjgnet.com/1948-0210/full/v18/i2/114032.htm
DOI: https://dx.doi.org/10.4252/wjsc.v18.i2.114032

Zhao YC, Li GY, Chen S, Wang YL, Feng JY, Cao Y. Epiregulin enhances periodontal tissue regeneration by promoting bone marrow mesenchymal stem cell functions under inflammatory niches. World J Stem Cells 2026; 18(2): 114032 [PMID: 41808890 DOI: 10.4252/wjsc.v18.i2.114032]

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