Human bone marrow-derived mesenchymal stem cells alleviate fluoxetine-resistant depression-like behaviors in mice by multi-target effects in the hippocampus

doi:10.4252/wjsc.124640

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Oct 26, 2026; 18(10): 124640
Published online Oct 26, 2026. doi: 10.4252/wjsc.124640

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Figure 10 Proposed mechanisms underlying the antidepressant effects of human bone marrow-derived mesenchymal stem cells in fluoxetine-resistant depression. The figure was created with BioRender.com. FRD: Fluoxetine-resistant depression; CURS: Chronic unpredictable restraint stress; CORT: Corticosterone; SPT: Sucrose preference test; FST: Forced swim test; TST: Tail suspension test; BDNF: Brain-derived neurotrophic factor; TrkB: Tropomyosin receptor kinase B; TH: Tyrosine hydroxylase; GFAP: Glial fibrillary acidic protein; IL-10: Interleukin-10; Arg1: Arginase 1; TGF: Transforming growth factor; hBMSCs: Human bone-marrow-derived mesenchymal stem cells; Iba1: Ionized calcium-binding adapter molecule 1; TNF: Tumor necrosis factor.

Citation: Liu Y, Wu JF, Xu MY, Kang J, Ye AH, Liu B, Liu KZ. Human bone marrow-derived mesenchymal stem cells alleviate fluoxetine-resistant depression-like behaviors in mice by multi-target effects in the hippocampus. World J Stem Cells 2026; 18(10): 124640
URL: https://www.wjgnet.com/1948-0210/full/v18/i10/124640.htm
DOI: https://dx.doi.org/10.4252/wjsc.124640

Liu Y, Wu JF, Xu MY, Kang J, Ye AH, Liu B, Liu KZ. Human bone marrow-derived mesenchymal stem cells alleviate fluoxetine-resistant depression-like behaviors in mice by multi-target effects in the hippocampus. World J Stem Cells 2026; 18(10): 124640 [DOI: 10.4252/wjsc.124640]

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