Human bone marrow-derived mesenchymal stem cells alleviate fluoxetine-resistant depression-like behaviors in mice by multi-target effects in the hippocampus

Figure 8 Human bone marrow-derived mesenchymal stem cells promoted the proliferation of newborn hippocampal neurons in stressed mice. A: Representative immunofluorescence images of DCX in the dentate gyrus (DG) region of the hippocampus; B: Quantification of DCX in the DG region; C: Representative immunofluorescence images of BrdU in the DG region of the hippocampus; D: Quantification of BrdU in the DG region. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. Data were analyzed using one-way analysis of variance followed by Tukey’s multiple-comparisons test (mean ± SEM, n = 5 per group for B, n = 3 per group for D). FLX: Fluoxetine; hBMSCs: Human bone-marrow-derived mesenchymal stem cells.