Human umbilical cord mesenchymal stem cells repair islet structure and function in diabetic rats through metabolic reprogramming

Table 4 Results of correlation analysis between key differential metabolites and biochemical indicators in the diabetes mellitus + human umbilical cord mesenchymal stem cells group vs diabetes mellitus group

Biochemical index	Differential metabolite ID	Correlation coefficient	P value
C-peptide	MW0152097	-0.874717531	< 0.001
C-peptide	MW0006200	-0.943054838	< 0.001
C-peptide	MW0148399	-0.86560589	< 0.001
C-peptide	MW0149707	-0.797268583	< 0.01
C-peptide	MW0114597	0.76993366	< 0.01
C-peptide	MW0151632	-0.815491865	< 0.01
C-peptide	MW0154243	-0.829159327	< 0.01
C-peptide	MW0155794	-0.829159327	< 0.01
C-peptide	MW0012191	-0.788156942	< 0.01
C-peptide	MW0144473	0.829159327	< 0.01
C-peptide	MEDP1343	-0.742598738	< 0.01
C-peptide	MW0054549	0.76993366	< 0.01
C-peptide	FDATN00900	0.774489481	< 0.01
C-peptide	MW0113931	0.760822019	< 0.01
C-peptide	MW0152407	0.760822019	< 0.01
C-peptide	MW0055257	0.824603506	< 0.01
C-peptide	MEDP1339	-0.619591585	< 0.05
C-peptide	MW0123548	-0.697040533	< 0.05
C-peptide	MW0015937	-0.66970561	< 0.05
C-peptide	MW0014969	-0.66970561	< 0.05
C-peptide	MEDN0785	-0.678817251	< 0.05
C-peptide	MW0055456	-0.683373071	< 0.05
C-peptide	MEDTN02450	-0.706152174	< 0.05
C-peptide	ZINC1629864	-0.605924123	< 0.05
FINS	MW0152097	-0.872727273	< 0.001
FINS	MW0149707	-0.918181818	< 0.001
FINS	MW0154243	-0.945454545	< 0.001
FINS	MW0113931	0.927272727	< 0.001
FINS	MW0151632	-0.781818182	< 0.01
FINS	MW0155794	-0.827272727	< 0.01
FINS	MW0014969	-0.790909091	< 0.01
FINS	MW0054549	0.8	< 0.01
FINS	MW0148399	-0.8	< 0.01
FINS	MW0055257	0.827272727	< 0.01
FINS	MW0144473	0.618181818	< 0.05
FINS	MW0123754	0.681818182	< 0.05
FINS	MW0006200	-0.7	< 0.05
FINS	MW0152407	0.7	< 0.05
FINS	MEDTN02450	-0.681818182	< 0.05
FINS	MW0128176	-0.672727273	< 0.05
FBG	MW0054549	-0.851938429	< 0.001
FBG	MW0152097	0.742598738	< 0.01
FBG	MW0149707	0.76993366	< 0.01
FBG	MW0151632	0.756266199	< 0.01
FBG	MW0154243	0.756266199	< 0.01
FBG	MW0155794	0.738042917	< 0.01
FBG	MW0123754	-0.820047686	< 0.01
FBG	MW0113931	-0.774489481	< 0.01
FBG	MW0128176	0.738042917	< 0.01
FBG	MW0053755	-0.706152174	< 0.05
FBG	MW0123548	0.728931276	< 0.05
FBG	MW0144473	-0.615035764	< 0.05
FBG	MW0014969	0.683373071	< 0.05
FBG	MW0006200	0.610479944	< 0.05
FBG	MW0152407	-0.615035764	< 0.05
FBG	MW0148399	0.642370687	< 0.05
FBG	MW0055257	-0.733487097	< 0.05
HOMA-IR	MW0123754	-0.890909091	< 0.001
HOMA-IR	MW0144473	-0.836363636	< 0.01
HOMA-IR	MW0006200	0.772727273	< 0.01
HOMA-IR	MW0055456	0.772727273	< 0.01
HOMA-IR	MW0152407	-0.8	< 0.01
HOMA-IR	MW0128176	0.772727273	< 0.01
HOMA-IR	MW0123548	0.727272727	< 0.05
HOMA-IR	MW0157815	0.690909091	< 0.05
HOMA-IR	MW0151632	0.681818182	< 0.05
HOMA-IR	MW0155794	0.618181818	< 0.05
HOMA-IR	MW0012191	0.745454545	< 0.05
HOMA-IR	MEDN0785	0.7	< 0.05
HOMA-IR	MW0054549	-0.618181818	< 0.05
HOMA-IR	FDATN00900	-0.681818182	< 0.05
HOMA-IR	MW0148399	0.727272727	< 0.05
HOMA-IR	MEDTN02450	0.654545455	< 0.05
HOMA-IR	MW0055257	-0.663636364	< 0.05
GHb	MW0054549	-0.872727273	< 0.001
GHb	MW0055257	-0.936363636	< 0.001
GHb	MW0152097	0.854545455	< 0.01
GHb	MW0149707	0.827272727	< 0.01
GHb	MW0151632	0.781818182	< 0.01
GHb	MW0155794	0.790909091	< 0.01
GHb	MW0144473	-0.809090909	< 0.01
GHb	MW0006200	0.8	< 0.01
GHb	MEDP1339	0.645454545	< 0.05
GHb	MW0053755	-0.663636364	< 0.05
GHb	MW0123548	0.690909091	< 0.05
GHb	MW0154243	0.745454545	< 0.05
GHb	MW0012191	0.663636364	< 0.05
GHb	MW0123754	-0.618181818	< 0.05
GHb	MW0113931	-0.7	< 0.05
GHb	MW0152407	-0.645454545	< 0.05
GHb	MW0148399	0.636363636	< 0.05
GHb	MEDTN02450	0.745454545	< 0.05
GHb	ZINC1629864	0.690909091	< 0.05
GSP	MW0154243	0.872727273	< 0.001
GSP	MW0113931	-0.881818182	< 0.001
GSP	MW0148399	0.936363636	< 0.001
GSP	MW0015937	0.818181818	< 0.01
GSP	MW0006200	0.827272727	< 0.01
GSP	MW0054549	-0.772727273	< 0.01
GSP	MW0152407	-0.818181818	< 0.01
GSP	MW0152097	0.754545455	< 0.05
GSP	MW0149707	0.754545455	< 0.05
GSP	MW0123548	0.627272727	< 0.05
GSP	MW0114597	-0.645454545	< 0.05
GSP	MW0151632	0.727272727	< 0.05
GSP	MW0155794	0.754545455	< 0.05
GSP	MW0012191	0.636363636	< 0.05
GSP	MW0144473	-0.7	< 0.05
GSP	MW0106148	-0.618181818	< 0.05
GSP	MW0014969	0.690909091	< 0.05
GSP	MW0123754	-0.690909091	< 0.05
GSP	MEDTN02450	0.654545455	< 0.05
GSP	MW0055257	-0.754545455	< 0.05

FINS: Fasting insulin; FBG: Fasting blood glucose; HOMA-IR: Homeostasis model assessment of insulin resistance; GHb: Glycosylated hemoglobin; GSP: Glycosylated serum protein.