Human umbilical cord mesenchymal stem cells repair islet structure and function in diabetic rats through metabolic reprogramming

doi:10.4252/wjsc.122760

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Oct 26, 2026; 18(10): 122760
Published online Oct 26, 2026. doi: 10.4252/wjsc.122760

Table 2 Results of Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis for key differential metabolites

Pathway	Classification level 1	Classification level 2	P value	Enrichment score
PPAR signaling pathway	Organismal systems	Endocrine system	0.0037	268.6667
Choline metabolism in cancer	Human diseases	Cancer: Overview	0.0136	73.2727
Efferocytosis	Cellular processes	Transport and catabolism	0.0258	38.3810
Linoleic acid metabolism	Metabolism	Lipid metabolism	0.0343	28.7857
Phenylalanine, tyrosine and tryptophan biosynthesis	Metabolism	Amino acid metabolism	0.0427	23.0286
Neuroactive ligand-receptor interaction	Environmental information processing	Signaling molecules and interaction	0.0499	19.6585
Glycerophospholipid metabolism	Metabolism	Lipid metabolism	0.0677	14.3929
Folate biosynthesis	Metabolism	Metabolism of cofactors and vitamins	0.0701	13.8966
Ubiquinone and other terpenoid-quinone biosynthesis	Metabolism	Metabolism of cofactors and vitamins	0.0853	11.3521
Arachidonic acid metabolism	Metabolism	Lipid metabolism	0.0945	10.2025

Classification level 1 refers to the first-level classification, and classification level 2 refers to the second-level classification; P value < 0.05 indicates that the enriched pathways are statistically significant. PPAR: Peroxisome proliferator-activated receptor.

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Citation: Xu J, Yang X, Zhang HY, Wang LL, Luo YD, Yang SL, Zhou YJ, Liu Y, Yang XF. Human umbilical cord mesenchymal stem cells repair islet structure and function in diabetic rats through metabolic reprogramming. World J Stem Cells 2026; 18(10): 122760
URL: https://www.wjgnet.com/1948-0210/full/v18/i10/122760.htm
DOI: https://dx.doi.org/10.4252/wjsc.122760

Xu J, Yang X, Zhang HY, Wang LL, Luo YD, Yang SL, Zhou YJ, Liu Y, Yang XF. Human umbilical cord mesenchymal stem cells repair islet structure and function in diabetic rats through metabolic reprogramming. World J Stem Cells 2026; 18(10): 122760 [DOI: 10.4252/wjsc.122760]

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